Astellas to Present New Data on IZERVAYTM (avacincaptad pegol intravitreal solution) in Geographic Atrophy at AAO 2025 Annual Meeting
News October 09, 2025

Astellas to Present New Data on IZERVAYTM (avacincaptad pegol intravitreal solution) in Geographic Atrophy at AAO 2025 Annual Meeting

Presentations include long-term GATHER2 open-label extension data, real-world treatment patterns on safety, and biomarker insights on geographic atrophy disease progression

**Astellas to Share Latest Findings on IZERVAY™ for Geographic Atrophy at Ophthalmology Conference**

Astellas Pharma Inc. is set to present new and significant data on its innovative treatment, IZERVAY™ (avacincaptad pegol intravitreal solution), for Geographic Atrophy (GA) at the upcoming American Academy of Ophthalmology (AAO) 2025 Annual Meeting. The presentations will offer a comprehensive look at the long-term effects of IZERVAY™ and its impact on patients suffering from this debilitating eye disease.

Geographic Atrophy is an advanced form of age-related macular degeneration (AMD) that causes irreversible vision loss. Currently, there are limited treatment options available, making the development of effective therapies like IZERVAY™ crucial for patients at risk of blindness.

The data being presented by Astellas will include findings from the open-label extension of the GATHER2 clinical trial. This long-term study provides valuable insights into the sustained efficacy and safety profile of IZERVAY™ over an extended period. Researchers will be closely examining the data to understand how the treatment impacts the progression of GA and its long-term benefits for patients.

Beyond the clinical trial data, Astellas will also be sharing real-world treatment patterns related to the safety of IZERVAY™. This analysis will provide valuable information on how the drug performs in everyday clinical practice, offering ophthalmologists a better understanding of its potential side effects and how to manage them effectively. This information is crucial for informing treatment decisions and ensuring patient safety.

In addition to clinical and real-world data, the presentations will also delve into biomarker insights related to geographic atrophy disease progression. By analyzing specific biomarkers, researchers aim to gain a deeper understanding of the underlying mechanisms driving GA and how IZERVAY™ interacts with these pathways. This knowledge could potentially lead to the development of even more targeted and effective treatments in the future.

The AAO Annual Meeting is a premier event for ophthalmologists and vision scientists from around the globe. Astellas' presentations are expected to generate significant interest and discussion among attendees, further contributing to the understanding and management of geographic atrophy. The company's commitment to advancing research and developing innovative therapies like IZERVAY™ offers hope for patients living with this sight-threatening condition. The findings presented at AAO 2025 will likely shape future treatment strategies and improve the lives of individuals affected by geographic atrophy.
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